The application of pharmacogenetics in identifying single nucleotide polymorphisms (SNPs) in DNA sequences that cause clinically significant alterations in drug-metabolizing enzyme activities is ...

Grapefruit juice is more than a breakfast staple — it’s a potent enzyme inhibitor that can dramatically alter how certain drugs are metabolized. This article explores how a tiny structural difference ...

Cynomolgus monkeys (Macaca fascicularis) and common marmosets (Callithrix jacchus) serve as critical models for drug metabolism studies due to their close genetic and physiological parallels with ...

Tirzepatide is one of the drugs that has revolutionized the treatment of obesity and other conditions such as diabetes in recent years. Despite its clinical success, its precise molecular and cellular ...

Cinnamon is one of the oldest and most commonly used spices in the world, but a new study from the National Center for Natural Products Research indicates a compound in it could interfere with some ...

Acyl glucuronides represent a crucial class of metabolites generated through the glucuronidation of carboxylic acid-containing compounds. In the realm of drug metabolism, these conjugates are formed ...

A new approach to weight loss research is challenging one of the biggest assumptions behind popular weight loss drugs: Are ...

A new combination of existing drugs reduces the size of cancerous tumors much more effectively than current treatments. A new drug lead shows promise that it could reduce the size of cancerous tumors ...

This article is based on a poster originally authored by Daniel A. Barr, Mario Öeren, Peter A. Hunt, Jonathan D. Tyzack, Tomáš Chrien, Tamsin E. Mansley and Matthew D. Segall, which was presented at ...

If you’re confused about the growing landscape of weight loss drugs, here is a concise breakdown of their mechanisms, ...

Scientists are experimenting with a novel approach to treating Alzheimer's disease in mice. They're using a drug that helps the brain make energy. NPR's Jon Hamilton says in a mouse, at least, the ...