Most neurons that die in Alzheimer’s disease do not simply starve or get smothered by amyloid plaques. According to a study ...

Glutamate is the main excitatory neurotransmitter and is essential for many important processes in the brain. In accordance with glutamate’s importance in the brain, there are many different types of ...

The difference between mental health and mental illness can turn on changes in brain cells and their connections that are almost incomprehensibly tiny, at least in physical terms. This irony is ...

Drugs that act on NMDA (N-methyl-D-aspartate) receptors, which are essential for learning, memory and moment-by-moment consciousness, are key for treating neuropsychiatric disorders. These drugs were ...

For all glutamate-gated channels, agonist-binding in the cleft formed by two dynamic lobes, D1 and D2, of ligand-binding domains (LBDs) is the event that energizes resting receptors to either open or ...

It remains difficult to distinguish anti-NMDA receptor encephalitis from a primary psychiatric disorder, but recent studies have identified clinical features and proposed screening criteria that could ...

Gainesville, FL - Temporal summation of repeated pain stimuli, also known as "windup" pain, is mediated by N-methyl-D-aspartate (NMDA) receptors, and this pathway has long been suspected of ...

A new study suggests a potential molecular strategy for treating fragile X syndrome, an inherited neurodevelopmental disorder that causes autism spectrum disorder and intellectual disability. This ...

One of several types of ligand-gated ion channel, the N-methyl-D-aspartate (NMDA) receptor transmits excitatory stimuli in the brain. When calcium flows through this channel, neural plasticity happens ...