This work was financially supported by the National Natural Science Foundation of China (32172402), Zhejiang Provincial Natural Science Foundation of China (LZ26C140005), and the Hangzhou Normal ...

This contribution is part of the special series of Inaugural Articles by members of the National Academy of Sciences elected in 2020. Amyloid-β (Aβ) fibrils exhibit self-propagating, molecular-level ...

First-in-human, phase 1/2 study of GSK4524101, an oral DNApolymerase theta inhibitor (POLQi), alone or combined with the poly(ADP-ribose) polymerase (PARP) inhibitor (PARPi) niraparib in adults with ...

Janus kinase (JAK) inhibitors, including baricitinib, block cytokine signaling and are effective disease-modifying treatments for several autoimmune diseases. Whether baricitinib preserves β-cell ...

Casomorphins are peptides formed by the enzymatic breakdown of the milk protein casein during digestion. The peptides typically contain from three to eight amino acids. Casein in milk produced by ...

Over 40 years have passed since the first randomized placebo‐controlled trials demonstrated a mortality benefit of β‐blockers (BBLs) after acute myocardial infarction (MI). 1 Since that time, primary ...

β-thalassemia is a disease caused by genetic mutations including a nucleotide change, small insertions or deletions in the β-globin gene, or in rare cases, gross deletions into the β-globin gene.

The transforming growth factor-β (TGF-β) signaling plays a critical role in the development and tissue homeostasis in metazoans, and deregulation of TGF-β signaling leads to many pathological ...

Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Engineering Plastics, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, P. R. China University of Chinese ...

fDepartment of Medicine, Department of Pharmacology, Department of Molecular Biology and Microbiology, Department of Biochemistry, and Case Center for Proteomics and Bioinformatics, Case Western ...